Necrolytic Migratory Erythema–like Skin Lesion During Gefitinib Treatment

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Glucagonoma and necrolytic migratory erythema.

blood tests were normal except for glucose: 145 mg/dL. Baseline plasma glucagon levels were 1200 pg/mL. Serum zinc was 97 mcg/dL. An abdominal CT scan showed a large mass involving the body and tail of the pancreas. A distal pancreatectomy with splenectomy was performed and no evidence of metastatic disease was observed. The skin rash cleared within a week after the operation and the patient re...

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Glucagonoma syndrome associated with necrolytic migratory erythema.

INTRODUCTION glucagonoma is a pancreatic neuroendocrine tumor derived from alpha-cells of the islets of Langerhans. It is marked by tumoral autonomous production of glucagon and characterized, among other symptoms, by necrolytic migratory erythema, an erythematous circinate lesion with areas of necrosis and sloughing. This is a rare disease with worldwide incidence estimated at 1 case per 20 mi...

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Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.

Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female p...

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Necrolytic migratory erythema in a patient with neuroendocrine carcinoma.

Necrolytic migratory erythema is an obligatory paraneoplastic syndrome. Here we describe a patient with a neuroendocrine tumor of probably pancreatic origin. She developed the typical skin lesions under chemotherapy with temozolomide and capecitabine.

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Necrolytic migratory erythema associated with hyperglucagonemia and neuroendocrine hepatic tumors.

We present a 61-year-old man with a 2-year history of persistent disseminated, psoriasiform annular pruritic lesions, acrodermatitis, weight loss, anemia and diabetes. Histopathology of the affected skin showed nonspecific subacute psoriasiform dermatitis. The computed tomographic scan of the abdomen revealed multiple hepatic tumors. Histopathological examination of ultrasound-guided needle bio...

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ژورنال

عنوان ژورنال: JAMA Dermatology

سال: 2016

ISSN: 2168-6068

DOI: 10.1001/jamadermatol.2016.1098